Clive Owen is an Academy Award -nominated, and Golden Globe- and BAFTA-award winning English actor. Owen appeared in the West End and Broadway hit play Closer, by Patrick Marber, which again became a film, and was released in 2005. It is interesting to note that he played "Dan" in the play, but was "Larry" the dermatologist in the film version. His blistering, darkly comic portrayal of Larry in the film version earned him a lot of recognition as well as the Golden Globe and BAFTA award and an Academy Award nomination for Best Supporting Actor. He noted that the expectations of him since the Oscar nomination have not changed the way he approaches film-making, stating "I try, every film I do, to be as good as I can and that's all I can do. After Closer, he appeared in Derailed alongside Jennifer Aniston, the comic book thriller Sin City as the noir antihero Dwight McCarthy and as a mysterious bank robber in Inside Man. Despite public denials, Owen had long been rumored to be a possible successor to Pierce Brosnan in the role of James Bond. A public opinion poll in the United Kingdom in October 2005 (SkyNews) found that he was the public's number one choice to star in the next installment of the series. In that same month, however, it was announced that British actor Daniel Craig would become the next James Bond. In an interview in the September 2007 issue of Details, he claimed that he was never offered or even approached concerning the role.[6] In 2006, Owen spoofed the Bond connection by making an appearance in the remake of The Pink Panther in which he plays a character named "Nigel Boswell, Agent 006" (when he introduces himself to Inspector Clouseau he quips that Owen's character is "one short of the big time"). In 2006, Owen starred in the highly acclaimed Children of Men. He received widespread praise for his role as the former political activist-turned-reluctant hero Theo Faron. The film was nominated for various awards including an Academy Award for Best Adapted Screenplay; Owen worked on the screenplay, although he was uncredited. The next year he starred alongside Paul Giamatti in the film Shoot 'Em Up and appeared as Sir Walter Raleigh opposite Cate Blanchett's Elizabeth I of England in the film Elizabeth: The Golden Age. Also in 2007, Owen appeared in the Christmas special of the Ricky Gervais show Extras, as revealed in the video podcast teaser.

Effects of Steroids

The kind of binding the steroids have to hormones determines the immediate effects of steroids in the brain. Androgen (male sex hormone) and estrogen (female sex hormone) receptors on the surface of a cell attract steroids. The steroid–receptor complex affects the cell nucleus and can influence patterns of gene expression. Because of this, the acute effects of steroids in the brain are substantially different from those of other drugs. Steroids are not euphorigenic, and do not trigger rapid increases in the neurotransmitter dopamine, which is responsible for the high that often drives substance abuse behaviors. However, long term steroid use eventually influences the same brain pathways and affects chemicals such as dopamine, serotonin and opioid systems. Considering the combined effect of their complex direct and indirect actions, it is not surprising that Steroids can affect mood and behavior in significant ways.

Internal Medicine

Doctors of internal medicine focus on adult medicine and have had special study and training focusing on the prevention and treatment of adult diseases. At least three of their seven or more years of medical school and postgraduate training are to learning how to prevent, diagnose, and treat diseases that affect adults. Internists are sometimes known as the doctor's doctor, because they act as consultants to other physicians to help solve puzzling diagnostic problems. Internists can choose to focus their practice on general internal medicine, or may take additional training to sub-specialize in one of 13 areas of internal medicine. Cardiologists, for example, are doctors of internal medicine who sub-specialize in diseases of the heart. The training an internist receives to sub-specialize in a particular medical area is both broad and deep. Subspecialty training usually requires an additional one to three years beyond the standard three-year general internal medicine residency. Internal medicine is the medical specialty dealing with the prevention, diagnosis, and treatment of adult diseases. Doctors of internal medicine, also known as internists, are sometimes the doctor's doctor, because other physicians consult them to help solve puzzling diagnostic problems. They are especially skilled in the management of patients who have undifferentiated or multi-system disease processes. An internist cares for hospitalized and ambulatory patients and may play a major role in teaching or research. Internal medicine is also a type of veterinary specialty. The term internal medicine comes from the German term "Innere Medizin," popularized in Germany in the late 19th century to describe physicians who combined the science of the laboratory with the care of patients. Many early-20th-century American doctors studied medicine in Germany and brought this medical field to the United States. Specialists in internal medicine are internists in the United States. In modern practice, most internists are subspecialists; that is, in general, they limit their medical practice to problems of one organ system or to one particular area of medical knowledge. For example, gastroenterologists and nephrologists specialize in diseases of the gut and the kidneys, respectively.